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H-THR(TBU)-OH

  • CAS No.: 4378-13-6
  • Purity: 99%
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1.What is the H-THR(TBU)-OH ?

O-tert-Butyl-L-threonine is a catalyst used in direct asymmetric Mannich, Mannich-type, and adol reaction involving unmodified α-hydroxyketones.

methyl (2S,3R)-2-amino-3-(tert-butoxy)butanoate
24205-25-2

methyl (2S,3R)-2-amino-3-(tert-butoxy)butanoate

(O-tert-butyl)-L-threonine
4378-13-6,201353-89-1

(O-tert-butyl)-L-threonine

Conditions
Conditions Yield
With water; sodium hydroxide; In acetone; at 20 - 25 ℃; for 3h; pH=11 - 12;
Fmoc-Thr(tBu)-OH
71989-35-0,138797-71-4

Fmoc-Thr(tBu)-OH

(O-tert-butyl)-L-threonine
4378-13-6,201353-89-1

(O-tert-butyl)-L-threonine

Conditions
Conditions Yield
With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; for 12h;
97%
With piperidine; In tetrahydrofuran; for 4h;
With triethylamine; In dichloromethane; at 20 ℃; for 4h;
277 mg

2.What is the CAS number for H-THR(TBU)-OH ?

The CAS number of H-THR(TBU)-OH is 4378-13-6.

More information of H-THR(TBU)-OH 4378-13-6 are:

CAS?Number

4378-13-6

Density

1.055 g/cm3

Melting Point

244-247 °C

Boiling Point

275.3oC at 760 mmHg

Flash Point

120.3oC

Vapor Pressure

0.0014mmHg at 25°C

Refractive Index

1.464

HS CODE

29241990

PSA

72.55000

LogP

1.30220

Pka

2.14±0.10(Predicted)

3.What are another words for H-THR(TBU)-OH ?

Synonyms?for?H-THR(TBU)-OH 4378-13-6:Butyricacid, 2-amino-3-tert-butoxy-, L- (8CI);O-tert-Butyl-L-threonine;Threoninetert-butyl ether;

4.What is the molecular formula of H-THR(TBU)-OH?

The chemical formula of ?H-THR(TBU)-OH is?C8H17NO3 which containing 8 Carbon atoms,17 Hydrogen atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??H-THR(TBU)-OH?is 175.228.

5.What is H-THR(TBU)-OH (4378-13-6) used for?

H-THR(TBU)-OH, also known as O-tert-Butyl-L-threonine, is an amino acid derivative featuring a tert-butyl group and a hydroxyl group. It is known for its role as a catalyst in various organic reactions, particularly in asymmetric synthesis.

InChI:InChI=1/C8H17NO3/c1-5(6(9)7(10)11)12-8(2,3)4/h5-6H,9H2,1-4H3,(H,10,11)/t5-,6+/m1/s1

Relevant articles related to H-THR(TBU)-OH:

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Paragraph 0012-0014, (2019/01/23)

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Page/Page column 42, (2012/10/18)

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