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1,3-DIETHYL-5,6-DIAMINOURACIL Good Manufacturer supply High Quality 52998-22-8
- Molecular Formula:C8H14N4O2
- Molecular Weight:198.225
- Vapor Pressure:0.0043mmHg at 25°C
- Melting Point:88-98°C
- Refractive Index:1.548
- Boiling Point:278.3°Cat760mmHg
- PKA:4.40±0.70(Predicted)
- Flash Point:122.1°C
- PSA：96.04000
- Density:1.23g/cm3
- LogP:0.37660
1,3-DIETHYL-5,6-DIAMINOURACIL(Cas 52998-22-8) Usage
InChI:InChI=1/C8H14N4O2/c1-3-11-6(10)5(9)7(13)12(4-2)8(11)14/h3-4,9-10H2,1-2H3
52998-22-8 Relevant articles
Novel, Dual Target-Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B
Brockmann, Andreas,Doroz-P?onka, Agata,Ja?ko, Piotr,Kie?-Kononowicz, Katarzyna,Kuder, Kamil J.,Latacz, Gniewomir,Müller, Christa E.,Olejarz-Maciej, Agnieszka,Schabikowski, Jakub,Za?uski, Micha?
, (2020/04/20)
Annelated purinedione derivatives have b...
Separation and identification of an impurity from the istradefylline intermediate
Meng, Zihui,Wang, Hongyi,Wang, Yiyun,Xu, Haojie,Xu, Zhibin,Xue, Min,Zheng, Zhonghui
, p. 14493 - 14499 (2020/04/27)
Istradefylline is a selective adenosine ...
Improved synthesis technology of istradefylline
-
Paragraph 0013; 0014, (2018/04/28)
The invention provides an improved synth...
Inhibitory Effects of New Mercapto Xanthine Derivatives in Human mcf7 and k562 Cancer Cell Lines
Sultani, Haider N.,Ghazal, Rasha A.,Hayallah, Alaa M.,Abdulrahman, Loay K.,Abu-Hammour, Khaled,AbuHammad, Shatha,Taha, Mutasem O.,Zihlif, Malek A.
supporting information, p. 450 - 456 (2017/02/03)
A series of new 2-methyl-2-[(1,3-Diethyl...
52998-22-8 Process route
-
-
89073-60-9
6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione
-
-
52998-22-8
5,6-diamino-1,3-diethyluracil
Conditions
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide; sodium dithionite;
In
water;
for 0.5h;
|
98% |
|
With
sodium dithionite; ammonia;
In
water;
at 60 ℃;
|
80% |
|
With
ammonium hydroxide; sodium dithionite;
In
water;
at 60 ℃;
|
76% |
|
6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione;
With
ammonium hydroxide;
at 70 ℃;
for 0.5h;
With
sodium dithionite;
at 20 ℃;
for 0.5h;
|
|
|
With
sodium dithionite; ammonia;
In
water;
|
|
|
With
hydrogen;
In
methanol;
for 20h;
Time;
|
|
|
6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione;
With
potassium carbonate;
In
water;
at 30 - 50 ℃;
With
sodium dithionite;
In
water;
at 20 ℃;
for 1h;
|
|
|
With
sodium dithionite; ammonia;
In
water;
at 60 ℃;
for 0.583333h;
|
|
|
With
sodium dithionite;
|
|
|
With
hydrogen; nickel;
for 1h;
under 3750.38 Torr;
|
-
-
41740-15-2
6-amino-1,3-diethyluracil
-
-
52998-22-8
5,6-diamino-1,3-diethyluracil
Conditions
| Conditions | Yield |
|---|---|
|
6-amino-1,3-diethyluracil;
With
nitric acid; acetic acid;
In
water;
With
sodium dithionite; ammonia;
In
water;
Further stages.;
|
80% |
|
6-amino-1,3-diethyluracil;
With
nitric acid; acetic acid;
In
water;
Inert atmosphere;
With
sodium dithionite; ammonia;
In
water;
Inert atmosphere;
|
80% |
|
Multi-step reaction with 2 steps
1.1: aq. AcOH / 0.5 h / 75 °C
1.2: NaNO2 / 1 h / 20 °C
2.1: aq. NH3 / 0.5 h / 70 °C
2.2: Na2S2O4 / 0.5 h / 20 °C
With
ammonium hydroxide; acetic acid;
|
|
|
Multi-step reaction with 2 steps
1: 74 percent / acetic acid; NaNO2 / H2O / 0.25 h / 50 - 60 °C
2: 80 percent / NH3; sodium dithionite / H2O / 60 °C
With
sodium dithionite; ammonia; acetic acid; sodium nitrite;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sodium nitrite / acetic acid / 0.25 h / 50 - 60 °C
2: ammonium hydroxide; sodium dithionite / water / 0.5 h
With
ammonium hydroxide; sodium dithionite; sodium nitrite;
In
water; acetic acid;
|
|
|
Multi-step reaction with 2 steps
1: cis-nitrous acid; acetic acid / water
2: sodium dithionite; ammonia / water
With
sodium dithionite; ammonia; cis-nitrous acid; acetic acid;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sodium nitrite; acetic acid / 20 - 60 °C
2: ammonium hydroxide; sodium dithionite / water / 60 °C
With
ammonium hydroxide; sodium dithionite; acetic acid; sodium nitrite;
In
water;
|
|
|
Multi-step reaction with 2 steps
1.1: acetic acid / 0.5 h
1.2: 1.5 h
2.1: hydrogen / methanol / 20 h
With
hydrogen; acetic acid;
In
methanol;
|
|
|
Multi-step reaction with 2 steps
1: acetic acid; sodium nitrite / water / 2.5 h / 20 °C
2: sodium dithionite; ammonia / water / 0.58 h / 60 °C
With
sodium dithionite; ammonia; acetic acid; sodium nitrite;
In
water;
|
|
|
Multi-step reaction with 2 steps
1: sodium nitrite / Acidic conditions
2: sodium dithionite
With
sodium dithionite; sodium nitrite;
|
|
|
Multi-step reaction with 2 steps
1: sodium nitrite; acetic acid / 0.5 h / 60 °C
2: nickel; hydrogen / 1 h / 3750.38 Torr
With
hydrogen; nickel; acetic acid; sodium nitrite;
|
52998-22-8 Upstream products
-
89073-60-9
6-amino-1,3-diethyl-5-nitroso-1H,3H-pyrimidine-2,4-dione
-
623-76-7
N,N'-diethylurea
-
41740-15-2
6-amino-1,3-diethyluracil
-
634-95-7
N,N-diethylurea
52998-22-8 Downstream products
-
142458-94-4
6-amino-1,3-diethyl-5-<<(dicyclopropylmethyl)carbonyl>amino>uracil
-
155271-02-6
(E)-8-(2,4-Dimethoxystyryl)-1,3-diethylxanthine
-
155270-98-7
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
-
147700-39-8
1,3-diethyl-8-(3,4,5-trimethoxy-styryl)-3,7-dihydro-purine-2,6-dione
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