Pharmaceutical
Current location:Home > Pharmaceutical
Factory sells Androstenedione 63-05-8 with sufficient production capacity
- Molecular Formula: C19H26O2
- Molecular Weight: 286.414
- Appearance/Colour: white to off-white solid
- Vapor Pressure: 1.2E-07mmHg at 25°C
- Melting Point: 170-171 °C(lit.)
- Refractive Index: 1.551
- Boiling Point: 431.4 °C at 760 mmHg
- Flash Point: 161.1 °C
- PSA： 34.14000
- Density: 1.11 g/cm3
- LogP: 4.08740
Androstenedione(Cas 63-05-8) Usage
|
Biological Metabolism |
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics. |
|
Safety Profile |
An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes. |
|
Purification Methods |
Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.] |
|
Definition |
ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads. |
InChI:InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
63-05-8 Relevant articles
Direct Observation of a Dienolate Intermediate in the Base-Catalyzed Isomerization of 5-Androstene-3,17-dione to 4-Androstene-3,17-dione
Pollack, Ralph M.,Mack, Joseph P. G.,Eldin, Sherif
, p. 5048 - 5050 (1987)
-
Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases
Tars, Kaspars,Olin, Birgit,Mannervik, Bengt
, p. 332 - 340 (2010)
Glutathione transferases (GSTs) are abun...
-
Prins,Reichstein
, p. 945,950 (1941)
-
Acid- and Base-Catalyzed Isomerization of Androst-5-ene-3,17-dione and 17α-Ethynyl-17β-hydroxy-5-estren-3-one
Perera, S. K.,Dunn, W. A.,Fedor, L. R.
, p. 2816 - 2821 (1980)
Isomerization of androst-5-ene-3,17-dion...
Determination of the Microscopic Rate Constants for the Base-Catalyzed Conjugation of 5-Androstene-3,17-dione
Pollack, Ralph M.,Zeng, Baifei,Mack, Joseph P. G.,Eldin, Sherif
, p. 6419 - 6423 (1989)
The hydroxide ion catalyzed isomerizatio...
Photochemical studies LII: investigation on the photostability of testosterone and methyltestosterone in the solid state
Reisch,Ekiz,Takacs
, p. 173 - 175 (1989)
-
Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin
Toth,Szecsi,Julesz,Faredin
, p. 160 - 168 (1997)
Activity and inhibition of 3β-hydroxyste...
REGIO- AND STEREOSELECTIVE 1,4-REDUCTIONS OF METHYLATED, CROSS-CONJUGATED STEROIDAL CYCLOHEXADIENONES
Kuenzer, H.,Stahnke, M.,Sauer, G.,Wiechert, R.
, p. 3859 - 3862 (1990)
Regio- and stereoselectivities in conjug...
Synthesis of Visible-Light–Activated Hypervalent Iodine and Photo-oxidation under Visible Light Irradiation via a Direct S0→Tn Transition
Matsuda, Yu,Matsumoto, Koki,Nagasawa, Sho,Nakajima, Masaya,Nemoto, Tetsuhiro
, p. 235 - 239 (2022/03/16)
Heavy atom-containing molecules cause a ...
Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B
Fejedelem, Zachary,Carney, Nolan,Nagorny, Pavel
, p. 10249 - 10262 (2021/07/31)
This article describes a concise synthes...
Electrochemically Enabled One-Pot Multistep Synthesis of C19 Androgen Steroids
Sommer, Florian,Kappe, C. Oliver,Cantillo, David
supporting information, p. 6044 - 6049 (2021/03/15)
The synthesis of many valuable C19 andro...
Platinum-Catalyzed α,β-Desaturation of Cyclic Ketones through Direct Metal–Enolate Formation
Chen, Ming,Dong, Guangbin
supporting information, p. 7956 - 7961 (2021/03/01)
The development of a platinum-catalyzed ...
63-05-8 Process route
-
-
1857-80-3
5α,6β-dibromocholestan-3β-ol
-
-
127-09-3
sodium acetate
-
-
64-19-7,77671-22-8
acetic acid
-
-
57-83-0
Progesterone
-
-
63-05-8
Androstenedione
-
-
302-97-6
androst-4-en-3-one-17β-carboxylic acid
-
-
1452-29-5
3-oxo-4-cholenic acid
Conditions
| Conditions | Yield |
|---|---|
|
at 80 ℃;
|
|
|
at 80 ℃;
|
-
-
1476-64-8,25706-90-5
androst-5-en-3β-ol
-
-
63-05-8
Androstenedione
-
-
10247-98-0
5-androsten-3-one
Conditions
| Conditions | Yield |
|---|---|
|
With
Celite; pyridinium chlorochromate;
In
dichloromethane;
for 2.5h;
Yields of byproduct given;
Ambient temperature;
|
63-05-8 Upstream products
-
58-22-0
testosterone
-
53-43-0
dehydroepiandrosterone
-
68-96-2
17-hydroxyprogesterone
-
521-17-5
5-androstenediol
63-05-8 Downstream products
-
58-22-0
17β-hydroxy-androst-4-en-3-one
-
1156-92-9
Androsten-(4) -diol-(3,17)
-
1229-12-5
5β-androstane-3,17-dione
-
2220-48-6
4,4-Dimethyl-5-Androsten-3,17-Dion
RELATED PRODUCTS
WANT TO
PURCHASE