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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

  • CAS No.: 874902-19-9
  • Purity: 99%
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Manufacturer supply top purity 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE 874902-19-9 with GMP standards

  • Molecular Formula: C17H17N5O
  • Molecular Weight: 307.355
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 87-88℃ 
  • Refractive Index: 1.64 
  • Boiling Point: 506.103 °C at 760 mmHg 
  • PKA: 0.01±0.10(Predicted) 
  • Flash Point: 259.882 °C 
  • PSA： 63.91000 
  • Density: 1.22 g/cm3 
  • LogP: 2.46060 

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE(Cas 874902-19-9) Usage

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

InChI:InChI=1/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

874902-19-9 Relevant articles

The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

Alexander, Jessica P.,Cravatt, Benjamin F.

, p. 9699 - 9704 (2006)

How lipid transmitters move within and b...

(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Holtfrerich, Angela,Hanekamp, Walburga,Lehr, Matthias

supporting information, p. 64 - 75 (2013/07/27)

Inhibitors of the enzymes fatty acid ami...

INHIBITORS OF FATTY ACID AMIDE HYDROLASE AND MONOACYLGLYCEROL LIPASE FOR MODULATION OF CANNABINOID RECEPTORS

-

Page/Page column 73, (2009/10/22)

Disclosed are compounds and compositions...

Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation

Ortar, Giorgio,Cascio, Maria Grazia,Moriello, Aniello Schiano,Camalli, Mercedes,Morera, Enrico,Nalli, Marianna,Di Marzo, Vincenzo

, p. 62 - 72 (2008/09/17)

We have synthesized a series of 18 1,5- ...

874902-19-9 Process route

5-[(1,1'-biphenyl)-4-ylmethyl]tetrazole

5-[(1,1'-biphenyl)-4-ylmethyl]tetrazole

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
874902-19-9

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
1010096-65-7

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Conditions
Conditions Yield
With triethylamine; In acetonitrile; at 0 - 50 ℃; for 7h;
16%
11%
5-((biphenyl-4-yl)methyl)-1H-tetrazole

5-((biphenyl-4-yl)methyl)-1H-tetrazole

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
874902-19-9

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
1010096-65-7

5-([1,1‘-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Conditions
Conditions Yield
With triethylamine; In acetonitrile; at 0 ℃; for 15h;
55%
32%

874902-19-9 Upstream products

  • 79-44-7
    79-44-7

    N,N-Dimethylcarbamoyl chloride

  • 31603-77-7
    31603-77-7

    4-biphenylacetonitrile

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